Modeling human neuromuscular diseases using patient iPS cells

 

The last years, remarkable progress has been made in the generation of spinal cord motor neurons (MNs) from human PSCs and induced PSCs. However, the ability of these MNs to connect and control human skeletal muscle remains uncertain. We will use the NMP differentiation system to generate in parallel spinal cord neurons and muscle cells from patient iPSCs. This will allow us to study the origin of disease and the contribution of either lineage (neural – muscle) to its pathology.

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In vitro differentiation of NMPs to neurons (Tuj1) and muscles (Desmin)

The Gouti Lab is actively involved in iMed, which includes five other Helmholtz centers in the Research Field Health besides the MDC. The program aims to interlink and coordinate the centers’ research activities in the field of personalized medicine and, through collaboration with local clinical partners, to promote the rapid transfer of research results into clinical practice.